HELIXOR P SERIE II


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Rudolf Steiner, founder of anthroposophy medical method, introduced mistletoe extract into oncology as an unconventional means of therapy for cancer in [ 20 ]. Improvement in HRQoL, positive influence in remission rate, and reduction of side effects were observed in most studies carried out on patients who received mistletoe extract in addition to chemotherapy [ 68 — 75 ]. Data analysis of the patients in therapy groups showed improvement in HRQoL, prolongation of relapse intervals, and reduction of side effects caused by tumor destructive therapies. Impact of complementary treatment of breast cancer patients with standardized mistletoe extract during aftercare: Triterpenoids and triterpenoid saponins of Viscum liquidambaricolum. The research findings demonstrated that Iscador M is able to prevent suppression of granulocyte burst activity triggered by surgical stress in breast cancer patients. Helixor A was administered subcutaneously to patients of the treatment group, while the control group received Lentinan intramuscularly.

In addition, the level of C-reactive proteins was not altered in the treatment group. Konrad U, Renatus Z. They also found new possibilities to investigate the therapeutic potential of VAP-A in breast cancer therapy caused by the existence of cytotoxic substances other than mistletoe lectin. Overall, there is evidence that mistletoe therapy may enhance the survival rate, improve HRQoL, and diminish the side effects of chemotherapy in breast cancer patients as concluded in many systematic reviews [ 76 — 87 ]. They found that different Helixor extracts have cytotoxic activity on tumor cells and also suggested that no growth stimulation of human cancer cell lines occurred. Cellular and Molecular Life Sciences. Album extracts as an antitumor drug, especially for breast cancer therapy.

From iii preclinical investigations discussed above, it is evident that various mistletoe extracts from different origins are capable of inducing apoptosis and cell death in human breast cancer cell lines.

Furthermore, long-term Iscador therapy induced a Th1 response to mistletoe. However, findings obtained from Semiglasov’s studies [ 7094 ] have verified that blinding may not necessarily have had relevant effects on the results of mistletoe studies. Furthermore, Iscador P was shown to be less effective in the induction of apoptosis and more effective in the induction of necrosis due probably to the presence of viscotoxins.

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In a recent study, a prospective clinical five-year follow-up trial has been designed to investigate the influence of mistletoe therapy in combination with chemotherapy on the helixof and overall survival time. However, the precise cellular and molecular mechanisms and the signal transduction pathways underlying the issue of how mistletoe extracts induced apoptosis helixkr not been completely revealed. Mistletoe treatments for minimising side effects of anticancer chemotherapy.

The activity of phoratoxin C was evaluated on the primary culture of human tumor cell from patients. Nelixor safety and effectiveness of mistletoe in cancer patients. Drugs of the Future. They all agree on this point that mistletoe extracts exhibit substantial cytotoxic effects in vitro and none of the studies reported growth stimulation and proliferation of tumor cell lines [ 50 — 62 ]. Another randomized, double blind, multicentre, and placebo controlled clinical trial was done by Semiglasov et al.

Immunostaining for proapoptotic specific proteins in Iscador Q treated cells, indicated involvement of the mitochondrial route, whereas Iscador M treated cells revealed involvement of both mitochondrial and death receptor pathways. Moreover, helxor researchers suggested combining mistletoe lectin with other forms of recognition receptor ligand substances to enhance the immune stimulatory effect.

Helixor P series II 7 ampoules 7 Ampullen

Journal of Experimental and Clinical Cancer Research. Lectins isolated from Ui mistletoe Viscum album coloratum induce apoptosis in tumor cells. In order to detect apoptotic pathways involved in Iscador induced programmed cell death, the cells were stained for several proapoptotic related components.

Mistletoe contains different types of biological active compounds such as carbohydrates, fats, amino acids, oligosaccharides, polysaccharides, enzyme, flavonoid, glycoprotein lectin MLTpolypeptide viscotoxinvesicles, and triterpene acids [ 23 — io ].

Preclinical and Clinical Effects of Mistletoe against Breast Cancer

Cytostatic effect occurred in a dose-dependent manner. No evidence of stimulation of human tumor cell proliferation by a standardized aqueous mistletoe extract in vitro.

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Their findings suggested possible relation of this protein to xerie group of phytohormone- cytokinin -binding proteins. Schaller G, Urech K. They used mistletoe lectin I along with adriamycin and interleukin 6 IL6 as reference compounds and carried out their studies using various human breast cancer cell lines. The cytotoxic activity of flavonoid compounds of isolated pachypodol and ombuine identified from Chinese mistletoe Viscum coloratum Kom, Nakai against MCF7 cell line has been demonstrated in vitro using MTT assay [ 51 hellixor.

It shows some immunostimulatory and cytotoxic effects against tumor cells [ 47 ].

A prospective randomized controlled clinical trial. Anemia during adjuvant non-taxane chemotherapy for early breast cancer: European Journal of Medical Research.

Intratumoral application of standardized mistletoe extracts down regulates tumor weight via decreased cell proliferation, increased apoptosis and necrosis in a murine model.

Efficacy and safety of mistletoe preparations viscum album for patients with cancer diseases. Mistletoe extracts standardised in terms of mistletoe lectins ML I in oncology: Stauder H, Kreuser E-D.

Individual patient data meta-analysis of survival and psychosomatic self-regulation from published prospective controlled cohort studies for long-term therapy of breast cancer patients with a mistletoe preparation iscador Evidence-Based Complementary and Alternative Medicine. An examination of relapse and survival time was carried out after a follow-up time of five years.

Die Mistel in der O Positive cytotoxic activity, no stimulation of tumor cell proliferation belixor observed. Abstract Breast cancer is among the most frequent types of cancer in women worldwide.